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Relation between serotoninergic brainstem dysfunction and epilepsy-related respiratory dysfunction in Dravet syndrome (seroDRAVET)


Strategic application domain: Biotech - Pharma

Application market: Neurology & Mental Health Disorders

Type of activity: Therapeutics, Pharma or Biotech


Our primary hypothesis is that occurrence of a seizure-induced fatal apnea in Dravet syndrome (DS) results from development of progressive epilepsy-related vulnerability to central respiratory dysfunction linked to brainstem serotonin (5HT) dysfunction. 


In the seroDRAVET project, we will: (i) analyze the temporal relationship between evolution of epilepsy and alteration of respiratory function in a model of DS, (ii) determine, both in rodents and in patients, the relation between alterations of the brainstem 5HT pathway and respiratory dysfunction, and (iii) validate that modulation of activity of 5HT neurons modifies the risk of seizure-related fatal apnea in DS. 


Project call


ANR Générique

PRC 2021




national project

On going

Duration: 48 months


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