Cancer Research Center of Lyon
Member of Lyonbiopole
The Cancer Research Center of Lyon (CRCL, UMR Inserm 1052 – CNRS 5286 – Centre Léon Bérard) is a research structure affiliated with the University Claude Bernard Lyon 1, the national health and research bodies (Inserm and CNRS), the Léon Bérard Comprehensive Cancer Centre (CLB) and with the Lyon University Hospitals (HCL) as clinical partners. The CRCL was officially created in January 2011 and its contract was recently renewed for the 2020-2026 period. It comprises 24 teams, totalling about 500 members, including 150 researchers and lecturers. The CRCL aims at increasing its international visibility and the attractiveness of the Lyon cancer research cluster, at facilitating the transfer of knowledge from fundamental cancer research to clinical applications in oncology, and at developing teaching and training in oncology.
One of the main goals of the CRCL is to support the development of strong translational research to enable patients to rapidly benefit from breakthroughs in basic research. This bridge from “bench to bedside” was rendered possible due to the strong collaboration between clinicians and pathologists of the CLB and HCL and scientific teams of the CRCL, creating a continuity between basic research and clinical applications.
The CRCL is directed by Patrick Mehlen, who is assisted by Charles Dumontet and Véronique Maguer-Satta as Deputy Directors.
Strategic Domain of Application: MedTech
Therapeutics areas: Oncology
Technologies: Genomics & Proteomics, Biochips, Imaging, Immunotherapy
Unit code: UMR INSERM 1052 / CNRS 5286 / UCBL / Centre Léon Bérard
Affiliation organization: CNRS, INSERM, UCBL (Université Claude Bernard Lyon 1)
Teams
Inflammasome and cancer
Inflammasomes, Cancer
Contact: Virginie Petrilli - virginie.petrilli@lyon.unicancer.fr
Stemness in gliomas
Stem cell, gliomas
Contact: Mathieu Gabut - mathieu.gabut@inserm.fr
Epigenetics, microenvironment and liver cancer
Epigenetics, Epigenomics, HCC
Contact: Massimo Levrero - massimo.levrero@inserm.fr
BMP, ecosystem, stemness and dynamic in cancer
Bone Morphogenetic Protein, Stem Cell, Tumor Niche
Contact: Véronique Maguer-Satta - veronique.maguer-satta@lyon.unicancer.fr
TGF-beta and immuno-regulation
Immunity, TGF-beta
Contact: Julien Marie - julien.marie@inserm.fr
Cancer cell death
Apoptose, Mitochondries, caspases
Contact: Gabriel Ichim - gabriel.ichim@lyon.unicancer.fr
Reprogramming, stem cells and oncogenesis
Oncogenesis, Reprogramming
Contact: Fabrice Lavial - fabrice.lavial@lyon.unicancer.fr
Oncopharmacology
Antibodies, Cancer
Contact: Charles Dumontet - charles.dumontet@chu-lyon.fr
Apoptosis, cancer and development
Dependence, Receptors
Contact: Patrick Mehlen - patrick.mehlen@lyon.unicancer.fr
Nuclear domains and pathologies
Ribosomes, Cancer development
Contact: Jean-Jacques Diaz - jean-jacques.diaz@lyon.unicancer.fr
Hepatitis viruses and pathobiology of chronic liver diseases
Hepatitis, Virus, Liver cancer
Contact: Fabien Zoulim - fabien.zoulim@inserm.fr
Cellular senescence, cancer and aging
Senescence, aging, cancer
Contact: David Bernard - david.bernard@lyon.unicancer.fr
Cell death and childhood cancers
cell death, pediatric cancers
Contact: Jean-Yves Blay Marie Castets - jean-yves.blay@lyon.unicancer.fr, marie.castets@lyon.unicancer.fr
Endocrine resistance, methylation and breast cancer
Breast cancer, Estrogen
Contact: Olivier Tredan Muriel Le Romancer - muriel.leromancer@lyon.unicancer.fr
Targeting non-canonical protein functions in cancer
Protein,
Contact: Toufic Renno - toufic.renno@lyon.unicancer.fr
Signaling, metabolism and tumor progression
EMT, TGFbeta, Metabolism
Contact: Germain Gillet - germain.gillet@lyon.unicancer.fr
Glioblastoma metabolism and heterogenetity, in 3D organoids
glioblastoma, organoids
Contact: Erika Cosset - erika.cosset@lyon.unicancer.fr
Genetics, epigenetics and biology of sarcomas
genetics, epigenetics, sarcoma
Contact: Franck Tirode - franck.tirode@lyon.unicancer.fr
Adhesion and signaling in metastatic melanoma
signaling, melanoma
Contact: Julien Ablain - julien.ablain@lyon.unicancer.fr
Cancer cell plasticity in melanoma
plasticity, melanoma
Contact: Stéphane Dalle Julie Caramel - julie.caramel@lyon.unicancer.fr
Cancer immune surveillance and therapeutic targeting
immunity
Contact: Christophe Caux - christophe.caux@lyon.unicancer.fr
Molecular regulation of cancer immunity
immunity
Contact: Yenkel Grinberg-Bleyer - yenkel.grinberg-bleyer@lyon.unicancer.fr
Small molecules for biological targets
molecules
Contact: Isabelle Krimm - isabelle.krimm@lyon.unicancer.fr
Integrated analysis of the dynamics of cancer
head and neck cancer,
Contact: Pierre Saintigny - pierre.saintigny@lyon.unicancer.fr
Address
19 Bd Jean XXIII 69008 LYON
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