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STEP : towards an innovative therapeutic approach of refractory epilepsies

 

 

The project called STEP (Synchrotron Therapy for EPilepsy), coordinated by Antoine Depaulis (Inserm Research Director at Grenoble Institute of Neuroscience) and funded by the National Research Agency, was launched on April 1st for a period of 4 years. This project, which brings together Grenoble teams from INSERM and CHU, the European Synchrotron Radiation Facility (ESRF), the IRMaGe imaging platform and the NuMeCan INRAE team in Rennes, aims to develop an innovative therapy for refractory epilepsies, using the unique properties of the synchrotron.

 

The need for new treatments for epilepsies

 

Epilepsy is a neurological disease that affects nearly 1% of the world's population (nearly 60 million patients), characterized by recurrent seizures and is often associated with cognitive and / or emotional impairments. Despite the discovery of several effective drugs, about a third of people with epilepsy cannot be treated effectively. For these people, the removal of the epileptic area of ​​the brain by neurosurgery is currently the therapeutic option of reference. This technique is effective in 50 to 80% of cases and the Grenoble University Hospital has more than 30 years of experience in this therapeutic approach and the clinical examinations it requires. However, this very invasive technique is risky and can be accompanied by side effects. The development of innovative, non-invasive and less risky therapeutic approaches is one of the first priorities in epilepsy research.

 

 

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