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Poxel Presents Preclinical Proof-of-Concept Data

LYON, France--(BUSINESS WIRE)-- POXEL SA (Euronext: POXEL - FR0012432516), a biopharmaceutical company focused on the development of innovative treatments for metabolic disorders, including type 2 diabetes, and liver diseases, including non-alcoholic steatohepatitis (NASH), today announced the poster presentation of proof-of-concept data for PXL770 in a biopsy-confirmed model of diet-induced NASH at the Global NASH Congress 2018 held in London, February 26-27, 2018. The results highlight PXL770 as a novel therapeutic approach in non-alcoholic fatty liver diseases (NAFLD), improving core disease symptoms. PXL770 directly activates adenosine monophosphate-activated protein kinase (AMPK), an enzyme that controls whole-body energy metabolism, de novo lipid synthesis, fatty acid oxidation and inflammation1. PXL770 is currently being assessed in a Phase 1b multiple ascending dose study in healthy volunteers.


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