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Poxel Presents New Preclinical Imeglimin Data on Improvement in Diastolic Function

Lyon, France, June 12, 2017 – POXEL SA (Euronext – POXEL - FR0012432516), a biopharmaceutical company focused on the development of innovative treatments for metabolic disorders, including type 2 diabetes, announced today that new preclinical Imeglimin data showing protective effects for diabetic cardiomyopathy in a rat model of metabolic syndrome was presented in a poster session at the 77th American Diabetes Association (ADA) Scientific Session at the San Diego Convention Center in San Diego, California.



“Diabetic cardiomyopathy is characterized by diastolic dysfunction, which is a significant cardiovascular complication affecting approximately 40 percent of the type 2 diabetic population and is associated with an increase in morbidity and mortality.*  Treatment options for this condition are limited and these exciting results show that Imeglimin has the potential to improve diastolic function and may reduce the burden of this prominent cardiovascular complication in type 2 diabetes patients,” commented Thomas Kuhn, CEO of Poxel. “These results are additive to previously presented data showing Imeglimin’s protective effect on endothelial dysfunction, which is the first step in the development of vascular disease in the context of cardiovascular complications resulting from type 2 diabetes.”



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