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GeNeuro Presents Data Supporting Role of Human Endogenous Retroviruses (HERVs) in Type 1 Diabetes

  • Data presented suggest pathogenic HERV-W envelope (Env) protein to be potential causal factor in Type 1 diabetes
  • Significant expression of pathogenic HERV-W Env found in pancreas of over 50% of Type 1 diabetes patients
  • GNbAC1, a humanized mAb targeting HERV-W Env, currently in Phase 2 study in Type 1 diabetes

 

 

 

12 June 2017 - 7:30am CEST - GeNeuro S.A. (Euronext Paris: CH0308403085 – GNRO), a biopharmaceutical company developing new treatments for neurological disorders and autoimmune diseases, announced today data supporting the link between human endogenous retroviruses (HERVs) and Type 1 diabetes (T1D). Data were presented at the 77th Scientific Sessions of the American Diabetes Association in San Diego, USA (June 9-13, 2017).

 

 

HERVs are ancestral, pro-viral, genetic elements, currently estimated to account for 8% of the human genome. Most HERVs are repressed, however in certain susceptible individuals, under pathological conditions, they can be transactivated and the resulting viral proteins appear to play a causal role in several autoimmune and neurodegenerative diseases.

 

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