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Two projects supported by Lyonbiopole recognised in the EquipEx+ call for Structuring Equipment for Research


The use of scientific equipment that meets the highest international standards in terms of performance has become a sine qua non for the competitiveness of French research. The E.S.R./EquipEx+ is a national project which aims to support new equipment  the main vocation of which is scientific research and the promotion of French scientific leadership. Within this framework, two projects from Auvergne-Rhône-Alpes supported by Lyonbiopôle have been selected: the Spatial-Cell-ID project and the InfectioTRON project.


Focus on these two projects :


The Spatial-Cell-ID project, coordinated by the École Normale Supérieure de Lyon should enable the creation of national equipment for space-time transcriptomics with cellular resolution.


The functions of cells and tissues depend on the fine regulation of genetic networks. For technical reasons, biologists have long been limited to observing gene expression at the scale of a whole tissue or organ. However, these tissues are made up of individual cells at different stages of development and with various forms and functions. These cellular singularities characterise a significant heterogeneity of gene expression between neighbouring cells. It is now essential to systematically characterise the spatial distribution of this heterogeneity and its dynamics over time in situ.  This equipment will make it possible to monitor the expression of all the genes in each cell while maintaining its spatial position within its tissue/organ/organization of origin, in a normal or pathological context. This is now possible thanks to very recent developments in spatial transcriptomics, combining genomics, imaging and bioinformatics.


This project, coordinated by the ENS de Lyon and supported by the Institut de Génomique Fonctionnelle de Lyon and the RDP, involves 11 research units and 67 teams from Lyon, international partners, private sector stakeholders and national networks in genomics, imaging and bioinformatics.



The InfectioTRON project, coordinated by Claude Bernard Lyon 1 University, aims to develop Lyon’s ecosystem to implement the “One Health” concept in the field of emerging infectious diseases.


The InfectioTron project offers a unique and coordinated network of complementary equipment and platforms enabling the multi-scale and multimodal analysis of infectious events from their natural environment to the analysis of the molecular and cellular mechanisms of infections, all within a high level of containment. It will support the development of new lines of research to carry out integrative projects within the "One Health" paradigm, linking the field to the laboratory. This will considerably strengthen the scientific community of the Auvergne-Rhône-Alpes region around the theme of infectious diseases in humans, animals and plants and will provide, de facto, a unique scientific environment in France. Moreover, the recent launch of the Veterinary Public Health Cluster underlines the desire for Lyon to become an international reference centre for One Health approaches.


This ambitious project will involve 10 research facilities (LBBE, CIRI, IVPC, MMSB, RS2GP, LBTI, IGFL, LEM, MAP, BF2I), five academic institutions (University Claude Bernard Lyon 1, ENS Lyon, VetAgro Sup, INSA, EPHE) and three national research organisations (CNRS, INSERM, INRAE).