3D ONCOCHIP

3D ONCOCHIP

3D ONCOCHIP est accrédité par Lyonbiopôle

Identity card

Global budget: 2189 k€

Public funding: 1165 k€

Public funders: Fonds Unique Interministériel (FUI) – DGCIS/Oséo, Grand Lyon, Grenoble Alpes Métropole, Région Rhône-Alpes

Call for projects: Autre

Year start: 2017

Completed project (2020-12)


Accredited by the French competitiveness cluster Lyonbiopôle

Co-accredited by the French competitiveness cluster Minalogic


Strategic business area: Human Medicines, In vitro Diagnostic

Application fields: Oncology

Technological approaches / Keywords: Biochips, Biomanufacturing, Cell model / Animal model, Drug delivery system

Stage of development at the beginning of the project: Discovery

Abstract

The goal of the project is to design micro-structured tumor for 4 types of cancer (breast, ovary, prostate, pancreas). This project is co-developed by CTI BIOTECH (Lyon) and MicroLight 3D, LMGP, LJK (Grenoble). The first step is the development of the 3D printing machine capable of creating the bio-frame (laser 2 photons). A bio-scaffold is the support for creating a three-dimensional tumor model. Indeed, a tumour does not consist of isolated cells but of an ecosystem in the space where tumour and environmental cells interact. The second step is the functionalization of the bio-scaffold to allow the cells to grow, thus approaching a real tumor. On these bio-structures, the different cell types - cancerous and environmental - are then printed by bio-extrusion. These cells, derived from tumour samples, are amplified at CTI BIOTECH. The last step is the optimization of techniques (software, production) and proof of concept prior to industrialization.


Objectives

The goal of the project is to develop Biological chips composed of human microtumours as a 3D in vitro model of cancerous human tissues that are both robust and reproducible in multi-well plate format (called microplate), for high throughput screening and oncology research.


Innovative assets
Highlights
Perspectives

Innovative assets

The 3D printing int its current use generally allows the micro-manufacturing of structure or the bioprinting of cells on surfaces of biomaterials more or less complex. The main technological leap of the 3DONCOCHIP project, in the field of Human Cellular Bioassays applied to Oncology, consists in a translational approach of 3D co-printing combining know-how and complementary technologies: - microprinting of bioscafflod: from microstructured and functionalized biomaterials allowing the creation of biological structures that can receive tumor cells in 3 ranges of formats for preclinical bioassays allowing screening of low, medium and high throughput drug candidates. - 3D bioprinting of tumour cells and accessory cells from the tumor environment using a technology of 3D bio-impression by extrusion on microstructured bio-frames. - functionalization of microstructured bio-frames by an innovative film technique

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