NATHEB

New therapeutic approaches in the treatment of chronic hepatitis B

NATHEB est accrédité par Lyonbiopôle

Identity card

Global budget: 4069 k€

Public funding: 2317 k€

Public funders: FEDER Rhône-Alpes, Fonds Unique Interministériel (FUI) – DGCIS/Oséo, Grand Lyon, Région Rhône-Alpes

Call for projects: FUI (FUI AAP8)

Year start: 2009

Completed project (2012-12)


Accredited by the French competitiveness cluster Lyonbiopôle


Strategic business area: Human Medicines

Application fields: Infectious diseases

Technological approaches / Keywords: Cell model / Animal model, Functional Screening / Drug discovery, In silico modeling, Structural Biology

Stage of development at the beginning of the project: Discovery

Abstract

Hepatitis B is a major public health problem with more than 350 million persons chronically infected worldwide, 20 to 40% of them being at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Current antiviral therapy regimens do not induce a sustained virological response in the large majority of patients. The aim of this program is to support the accelerated development of two novel classes of agents to treat HBV chronic infections. Longer term outcome will be the development of an optimal clinical treatment combining both agents.


Objectives

The aim of the project is to develop a new efficient therapy against hepatitis B, which despite the efficacy of current vaccines, strikes over 350 million people in the world, and particularly in emerging countries. These new treatments will allow a better control over replication of the viral genome and viral antigen expression as well as a better stimulation of the host immune response.


Innovative assets
Highlights
Actual results
Perspectives

Innovative assets

Support the accelerated development of two novel classes of agents to treat HBV chronic infections. Longer term outcome will be the development of an optimal clinical treatment combining both agents.

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