BIOTHERAPIC

Development of therapeutic vaccines against Hepatitis C

BIOTHERAPIC est accrédité par Lyonbiopôle

Identity card

Global budget: 6323 k€

Public funding: 2385 k€

Public funders: Fonds Unique Interministériel (FUI) – DGCIS/Oséo

Call for projects: FUI (FUI AAP0)

Year start: 2005

Completed project (2009-11)


Accredited by the French competitiveness cluster Lyonbiopôle


Strategic business area: Human Medicines

Application fields: Infectious diseases

Technological approaches / Keywords: Immunotherapy, Vector vaccine

Stage of development at the beginning of the project: Preclinical development

Abstract

 “BIOTHERAPIC aimed at integrating regional expertise from Transgene, HCL, Grenoble CHU, lNSERM and CNRS. This innovative approach combined the evaluation of a vectorized immunotherapeutic product against Hepatitis C and the development of an antibody chip diagnostic assay. The objectives were largely achieved with the administration of the first immunotherapeutic candidate TG4040 in 51 patients in the chronic stage of infection. This Phase I  clinical trial demonstrated the vaccine safety and provided antiviral efficacy data.”  


Objectives

The aim of the program was to develop a prototype vectored therapeutic vaccine aiming at treating, either as stand-alone or in combination with small antiviral molecules, patients infected by the most worldwide prevalent viral genotype 1 strain of HCV. Different vectors and combination of viral immunogens were tested in vitro and in vivo. The objective was to achieve the pre-clinical proof-of-concept and provide safety and early efficacy data through the realization of a clinical phase I trial using the identified lead poxvirus-based candidate  therapeutic vaccine.


Innovative assets
Highlights
Actual results
Perspectives

Innovative assets

Development of therapeutic vaccines against Hepatitis C

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