Strategic area of application
Human Medicine
Application market
Oncology
Activities
Therapeutics, Pharma or Biotech - CRO
Technologies
Cell Therapy - cell biology - Biobanking - Antibodies - Protein - Peptide - Others
Presentation of company's activity
Advanced BioDesign (ABD) is a biotechnology company whose activity focuses on the development of pharmaceutical products, biological products, reagents for research and development as well as various kits for the biomedical diagnostic.
Recent news
Product pipeline 1
Therapeutic area: Cancer Treatment
Therapeutic indication: AML, Solid Tumors
Preclinical: PdC
Presentation of company's technologies
DIMATE targets and inhibits a detoxification system present within cells. This detoxification is strongly active in most tumor or leukemic cells, enabling them to survive the inevitable metabolic disorders which occur during the cancer process. By inhibiting this cellular protection system, DIMATE poisons and kills off cancer cells, without harming healthy cells.
In most cancers, there is also a population of cells, so called “cancer stem cells”, which are most often highly resistant to the cytotoxic effects of current anti-cancer drugs. This resistance to treatment appears to be the main cause of regular relapses of cancer. In studies carried out by the Advanced BioDesign team, DIMATE also destroys these cancer stem cells. Because of this specific property, which is a result of its molecular mechanism of action, DIMATE could be a particularly important drug in preventing cancers from recurring.
Its mechanism of action also means that DIMATE should be able to strengthen the anti-tumor action of all drugs and therapies activating the redox system, such as platinum salts and gamma rays, and therefore overcome primary resistance to these treatments.
Collaboration framework
Collaboration with APHM- La Conception, Inserm, CLB (Lyon) in France and in Europe with Luxembourg Institute of Health, UAB at Barcelone, IMG at Prague.
Out-licencing opportunity
Out-licencing of many steps of our reglementary toxicology assays (ADME Tox, Genotoxicity, comparative K, formulations...), API characterization, synthesis of Drug Substence and Drug Product.
