Strategic area of application
Human Medicine
Application market
Immune, AutoIm & Inflam. diseases - Infectiology - Parasitology - Neurological diseases
Activities
Therapeutics, Pharma or Biotech - Technology provider
Technologies
Genomics & Proteomics, Biochips - Vaccine - Antibodies - Protein - Peptide
Presentation of company's activity
CALIXAR has developped a new innovative and patented technology for extraction of membrane proteins and antigens without denaturation. The technology is based on a multi-step extraction strategy and uses a specific serie of home-made non denaturing detergents.
CALIXAR offers its services to industries (pharma, biopharma, biotech) and academic teams which want to work on the right therapeutic or antigenic targets and which want to optimize and ensure the production of their target.
The technology can be applied from gene or from biological samples or line cells.
CALIXAR allows the production of high performance monoclonal/polyclonal antibodies, the development of high purity vaccines and reliable diagnostic tools, and the discovery of reliable leads by screening or better by drug design based on the 3D structure of membrane protein targets (more than 70% of the pharmaceutical market)
Key features of company
Non denaturing extraction technology
Best expression systems available (eucaryote and procaryote - cell free systems ...)
No refolding step
Structural and functional control of the target / antigen
Global service from gene to protein up to the structure
Full-lenght/integral membrane protein production in solution
Recent news
New R&D project on flue vaccine (optimization of H1 N1 antigen production with CALIXAR extraction process + development M2 flue vaccine)
Skills and know-how
Biochemistry of proteins in particular membrane proteins
Molecular Biology
Cellular Biology
Crystallization of membrane proteins
Organic chemistry
Out-licencing opportunity
Extraction / purification process could be licensed out especially for vaccine market
Cristallization process with special additives could be licensed out for distribution or use.
