CALIXAR SAS

Strategic area of application
Human Medicine

Application market
Immune, AutoIm & Inflam. diseases - Infectiology - Parasitology - Neurological diseases

Activities
Therapeutics, Pharma or Biotech - Technology provider

Technologies
Genomics & Proteomics, Biochips - Vaccine - Antibodies - Protein - Peptide

Presentation of company's activity

CALIXAR has developped a new innovative and patented technology for extraction of membrane proteins and antigens without denaturation. The technology is based on a multi-step extraction strategy and uses a specific serie of home-made non denaturing detergents.

CALIXAR offers its services to industries (pharma, biopharma, biotech) and academic teams which want to work on the right therapeutic or antigenic targets and which want to optimize and ensure the production of their target.

The technology can be applied from gene or from biological samples or line cells.

CALIXAR allows the production of high performance monoclonal/polyclonal antibodies, the development of high purity vaccines and reliable diagnostic tools, and the discovery of reliable leads by screening or better by drug design based on the 3D structure of membrane protein targets (more than 70% of the pharmaceutical market)

Key features of company

Non denaturing extraction technology

Best expression systems available (eucaryote and procaryote - cell free systems ...)

No refolding step

Structural and functional control of the target / antigen

Global service from gene to protein up to the structure

Full-lenght/integral membrane protein production in solution

Recent news
New R&D project on flue vaccine (optimization of H1 N1 antigen production with CALIXAR extraction process + development M2 flue vaccine)
 

Skills and know-how

Biochemistry of proteins in particular membrane proteins

Molecular Biology

Cellular Biology

Crystallization of membrane proteins

Organic chemistry

Out-licencing opportunity

Extraction / purification process could be licensed out especially for vaccine market

Cristallization process with special additives could be licensed out for distribution or use.